Discontinue taking pill if signs of thrombosis occur. Not for protection against HIV infection (AIDS) or any other STD. Not to be used in patients w/ hepatitis C. Smoking (especially women >35 yr); diabetes; overwt; high BP; heart valve or certain heart rhythm disorder; vein inflammation (superficial phlebitis); varicose veins; migraine; epilepsy; liver or gallbladder disease; Crohn's disease or ulcerative colitis (chronic inflammatory bowel disease); SLE; haemolytic uraemic syndrome; sickle cell disease; operation, prolonged immobilisation; hearing loss, porphyria, herpes gestationis, Sydenham's chorea; hereditary & acquired angioedema. History or presence of chloasma (avoid excessive sun or UV light exposure); high blood cholesterol or triglycerides. Family history of thrombosis, heart attack or stroke; high blood cholesterol or triglycerides; breast cancer. Benign & malignant liver tumours; severe diarrhea; unusual, heavy vag bleeding. Increased risk of blood clots in patients who recently gave birth. High risk of thrombosis especially during 1st yr of starting therapy & restarting after ≥4 wk. Increased occurrence of breast & cervical cancer in long term use. Glucose intolerance. Concomitant use w/ primidone, phenytoin, phenobarb, carbamazepine, oxcarbazepine, topiramate, felbamate; rifampicin; ritonavir, nelfinavir, nevirapine, efavirenz; boceprevir, telaprevir; griseofulvin; bosentan; St. John's wort; ciclosporin, lamotrigine; glecaprevir/pibrentasvir. Not to be used in combination drug regimen ombitasvir/paritaprevir/ritonavir w/ or w/o dasabuvir. May affect blood or urinary test results. Should not have sexual intercourse or take extra non-hormonal contraceptive precautions eg, use condom or another barrier method. Do not use rhythm or temp methods. Women of childbearing potential. Not to be used during pregnancy. Not recommended during lactation. Childn.
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